A ratiometric fluorescent probe for mitochondrial lipid peroxidation
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MitoPerOx

Item No. 18798

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2-(3-(5,5-difluoro-7-((1E,3E)-4-phenylbuta-1,3-dien-1-yl)-5H-5λ4,6λ4-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-3-yl)propanamido)ethyl)triphenylphosphonium, monobromide
CAS Number
1392820-50-6
Molecular Formula
C42H38BF2N3OP • Br
Formula Weight
760.5
Purity
≥90%
Emission
520-590 nm
Excitation
495 nm
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 25 mM
SMILES
[F-][B+3]1([N-]2C(CCC(NCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)=O)=CC=C2C=C(C=C6)[N]1=C6/C=C/C=C/C7=CC=CC=C7)[F-].[Br-]
InChi Code
InChI=1S/C42H37BF2N3OP.BrH/c44-43(45)47-35(18-14-13-17-34-15-5-1-6-16-34)25-27-37(47)33-38-28-26-36(48(38)43)29-30-42(49)46-31-32-50(39-19-7-2-8-20-39,40-21-9-3-10-22-40)41-23-11-4-12-24-41;/h1-28,33H,29-32H2;1H/b17-13+,18-14+;
InChi Key
UDTNTHFRCJAKLR-GPSHETCQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $636

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    Product Description

    MitoPerOx is a ratiometric fluorescent probe that can be used to assess changes in lipid peroxidation within mitochondria.1 It is composed of a BODIPY fluorophore conjugated via a dienyl link to a triphenylphosphonium cation component that drives its accumulation in mitochondria. MitoPerOx displays an excitation maximum of 495 nm and exhibits a shift in emission maxima from 590 to 520 nm upon mitochondrial lipid peroxidation, enabling determination of ratiometric measurements of lipid peroxidation in live cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Prime, T.A., Forkink, M., Logan, A., et al. A ratiometric fluorescent probe for assessing mitochondrial phospholipid peroxidation within living cells. Free Radic. Biol. Med. 53(3), 544-553 (2012).