A mitochondria-targeted redox cycler
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MitoPQ

Item No. 18808

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-methyl-1'-(10-(triphenylphosphonio)decyl)-[4,4'-bipyridine]-1,1'-diium iodide
CAS Number
1821370-28-8
Synonyms
  • ​MitoParaquat
Molecular Formula
C39H46N2P • 3I
Formula Weight
954.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mLDMF:PBS(pH 7.2)(1:2): 0.33 mg/mLDMSO: 1 mg/mLEthanol: 0.33mg/mL
SMILES
C[N+](C=C1)=CC=C1C(C=C2)=CC=[N+]2CCCCCCCCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5.[I-].[I-].[I-]
InChi Code
InChI=1S/C39H46N2P.3HI/c1-40-30-25-35(26-31-40)36-27-32-41(33-28-36)29-17-6-4-2-3-5-7-18-34-42(37-19-11-8-12-20-37,38-21-13-9-14-22-38)39-23-15-10-16-24-39;;;/h8-16,19-28,30-33H,2-7,17-18,29,34H2,1H3;3*1H/q+3;;;/p-3
InChi Key
AOZZGHKENAZYTD-UHFFFAOYSA-K
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $119

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    25 mg

    $268

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    50 mg

    $417

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    100 mg

    $714

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    Product Description

    MitoPQ is comprised of a triphenylphosphonium lipophilic cation conjugated to the redox cycler paraquat.1 Driven by membrane potential, it accumulates selectively in the mitochondrial matrix where it produces superoxide by redox cycling at the flavin site of complex I.1 Thus, MitoPQ selectively increases superoxide production within mitochondria and can be used as a tool either in cells or in vivo to investigate the role of mitochondrial superoxide in pathology and redox signaling.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Robb, E.L., Gawel, J.M., Aksentijevic, D., et al. Selective superoxide generation within mitochondria by the targeted redox cycler MitoParaquat. Free Radic. Biol. Med. 89, 883-894 (2015).