A dipeptide with antioxidant and anticataract activities
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N-acetyl-L-Carnosine

Item No. 18817

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-acetyl-β-alanyl-L-histidine
CAS Number
56353-15-2
Synonyms
  • NAC
Molecular Formula
C11H16N4O4
Formula Weight
268.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 0.5 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
OC([C@@H](NC(CCNC(C)=O)=O)CC1=CN=CN1)=O
InChi Code
InChI=1S/C11H16N4O4/c1-7(16)13-3-2-10(17)15-9(11(18)19)4-8-5-12-6-14-8/h5-6,9H,2-4H2,1H3,(H,12,14)(H,13,16)(H,15,17)(H,18,19)/t9-/m0/s1
InChi Key
BKAYIFDRRZZKNF-VIFPVBQESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

    $36

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    1 g

    $70

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    5 g

    $186

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    Product Description

    N-acetyl-L-Carnosine is a dipeptide and acetylated form of L-carnosine (Item No. 29825) that has been found in heart and skeletal muscle and has antioxidant and anticataract activities.1,2 It reduces iron- and ascorbate-induced malondialdehyde (MDA) accumulation in liposomes when used at concentrations of 10 and 20 mM.1 Topical administration of N-acetyl-L-carnosine (1% v/v) reduces cortical opacities in a canine model of age-related cataracts.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Babizhayev, M.A., Yermakova, V.N., Sakina, N.L., et al. N alpha-acetylcarnosine is a prodrug of L-carnosine in ophthalmic application as antioxidant. Clin. Chim. Acta 254(1), 1-21 (1996).

    2. Babizhayev, M.A., Deyev, A.I., Yermakova, V.N., et al. Lipid peroxidation and cataracts: N-acetylcarnosine as a therapeutic tool to manage age-related cataracts in human and in canine eyes. Drugs R. D. 5(3), 125-139 (2004).