A second messenger
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Cyclic GMP (sodium salt)

Item No. 18821

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
cyclic 3',5'-(hydrogen phosphate) guanosine, monosodium salt
CAS Number
40732-48-7
Synonyms
  • cGMP
  • Cyclic guanosine monophosphate
  • Guanosine 3'5'-cyclic monophosphate
  • Monosodium-GMP
Molecular Formula
C10H11N5O7P • Na
Formula Weight
367.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
Water: Slightly Soluble
λmax
256 nm
SMILES
O[C@H]1[C@H](N2C=NC3=C2N=C(N)NC3=O)O[C@@]4([H])[C@@]1([H])OP(OC4)([O-])=O.[Na+]
InChi Code
InChI=1S/C10H12N5O7P.Na/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6;/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17);/q;+1/p-1/t3-,5-,6-,9-;/m1./s1
InChi Key
KMPIYXNEROUNOG-GWTDSMLYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    50 mg

    $69

    Add

    250 mg

    $263

    Add
    Product Description

    Cyclic GMP (cGMP) is a second messenger that is biosynthesized from GTP by guanylate cyclases. Activators of guanylate cyclases include nitric oxide and natriuretic peptides.1 cGMP activates protein kinase G (PKG) and modulates ion channel conductance, with signaling affecting diverse processes including smooth muscle relaxation and proliferation, phototransduction, and energy homeostasis.1,2,3,4 The degradation of cGMP to GMP is mediated by specific and non-specific phosphodiesterases.5,6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hamad, A.M., Clayton, A., Islam, B., et al. Guanylyl cyclases, nitric oxide, natriuretic peptides, and airway smooth muscle function. Am. J. Physiol. Lung Cell. Mol. Physiol. 285(5), L973-L983 (2003).

    2. Tulis, D.A. Novel therapies for cyclic GMP control of vascular smooth muscle growth. Am.J.Ther. 15(6), 551-564 (2008).

    3. Koch, K.W., and Dell'Orco, D. Protein and signaling networks in vertebrate photoreceptor cells. Front.Mol.Neurosci. 8(67), (2015).

    4. Kim, G.W., Lin, J.E., Blomain, E.S., et al. Antiobesity pharmacotherapy: New drugs and emerging targets. Clin. Pharmacol. Ther. 95(1), 53-66 (2014).

    5. DeNinno, M.P. Future directions in phosphodiesterase drug discovery. Bioorg. Med. Chem. Lett. 22(22), 6794-6800 (2012).

    6. Rotella, D.P. Phosphodiesterase 5 inhibitors: Current status and potential applications. Nat. Rev. Drug Discov. 1(9), 674-682 (2002).