A GABAA receptor agonist
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Thiomuscimol

Item No. 18857

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(aminomethyl)-3(2H)-isothiazolone
CAS Number
62020-54-6
Molecular Formula
C4H6N2OS
Formula Weight
130.2
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
λmax
262 nm
SMILES
O=C1C=C(CN)SN1
InChi Code
InChI=1S/C4H6N2OS/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7)
InChi Key
QVBUOPGWPXUAHT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 µg

    $69

    Add

    1 mg

    $120

    Add

    5 mg

    $297

    Add

    10 mg

    $461

    Add
    Product Description

    Thiomuscimol is a GABAA receptor agonist (IC50 = 19 nM).1,2 It has been used as a photoaffinity label for the purification and identification of GABA binding sites within the GABAA receptor complex.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Melikian, A., Schlewer, G., Chambon, J.P., et al. Condensation of muscimol or thiomuscimol with aminopyridazines yields GABA-A antagonists. J. Med. Chem. 35(22), 4092-4097 (1992).

    2. Krogsgaard-Larsen, P., Hjeds, H., Curtis, D.R., et al. Dihydromuscimol, thiomuscimol and related heterocyclic compounds as GABA analogues. J. Neurochem. 32(6), 1717-1724 (1979).

    3. Nielsen, M., Witt, M.R., Ebert, B., et al. Thiomuscimol, a new photoaffinity label for the GABAA receptor. Eur. J. Pharmacol. 289(1), 109-112 (1995).