A reversible allosteric antagonist of mGluR7
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MMPIP (hydrochloride)

Item No. 18862

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-(4-methoxyphenyl)-5-methyl-3-(4-pyridinyl)-isoxazolo[4,5-c]pyridin-4(5H)-one, monohydrochloride
CAS Number
1215566-78-1
Molecular Formula
C19H15N3O3 • HCl
Formula Weight
369.8
Purity
≥98%
Formulation
A solid
SMILES
O=C1N(C)C(C2=CC=C(OC)C=C2)=CC3=C1C(C4=CC=NC=C4)=NO3.Cl
InChi Code
InChI=1S/C19H15N3O3.ClH/c1-22-15(12-3-5-14(24-2)6-4-12)11-16-17(19(22)23)18(21-25-16)13-7-9-20-10-8-13;/h3-11H,1-2H3;1H
InChi Key
HXHQNERSIJXMTQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
Room temperature
Shipping
Ambient in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $75

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    10 mg

    $202

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    50 mg

    $773

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    Product Description

    MMPIP is a reversible allosteric antagonist of the metabotropic glutamate receptor 7 (mGluR7) that blocks agonist-induced calcium mobilization (IC50 = 26 nM).1,2 It does not affect other mGlu receptors. The modulation of mGluR7 by MMPIP is context dependent, in that it is not observed in all known mGluR7 signaling pathways.2 MMPIP has been used to investigate the role of mGluR7 in cocaine-mediated reward signaling, attention and impulse control, and cognitive behavior in mice and rats.3,4,5 MMPIP also reversibly inhibits constitutive activity of mGluR7 in sympathetic neurons from the rat superior cervical ganglion.6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Suzuki, G., Tsukamoto, N., Fushiki, H., et al. In vitro pharmacological characterization of novel isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists. J. Pharmacol. Exp. Ther. 323(1), 147-156 (2007).

    2. Niswender, C.M., Johnson, K.A., Miller, N.R., et al. Context-dependent pharmacology exhibited by negative allosteric modulators of metabotropic glutamate receptor 7. Mol. Pharmacol. 77(3), 459-468 (2010).

    3. Li, X., Li, J., Peng, X.Q., et al. Metabotropic glutamate receptor 7 modulates the rewarding effects of cocaine in rats: Involvement of a ventral pallidal GABAergic mechanism. Neuropsychopharmacology 34(7), 1783-1796 (2009).

    4. Benn, A., and Robinson, E.S.J. Investigating glutamatergic mechanism in attention and impulse control using rats in a modified 5-choice serial reaction time task. PLoS One 9(12), (2014).

    5. Palazzo, E., Romano, R., Luongo, L., et al. MMPIP, an mGluR7-selective negative allosteric modulator, alleviates pain and normalizes affective and cognitive behavior in neuropathic mice. Pain 156(6), 1060-1073 (2015).

    6. Kammemeier, P.J. Constitutive activity of metabotropic glutamate receptor 7. BMC Neurosci. 16:17, (2015).