A cephalosporin antibiotic
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Ceftriaxone (sodium salt hydrate)

Item No. 18866

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(6R,7R)-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, disodium salt, hemiheptahydrate
CAS Number
104376-79-6
Synonyms
  • Ro 13-9904
Molecular Formula
C18H16N8O7S3 • 2Na [3.5H2O]
Formula Weight
661.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
λmax
241 nm
SMILES
O=C(C1NC(/C(C2=CSC(N)=N2)=N\OC)=O)N3[C@]1([H])SCC(CSC(N(C)N=C4[O-])=NC4=O)=C3C([O-])=O.O=C(C5NC(/C(C6=CSC(N)=N6)=N\OC)=O)N7[C@]5([H])SCC(CSC(N(C)N=C8[O-])=NC8=O)=C7C([O-])=O.O.O.O.O.O.O.[Na+].[Na+].O.[Na+].[Na+]
InChi Code
InChI=1S/2C18H18N8O7S3.4Na.7H2O/c2*1-25-18(22-12(28)13(29)23-25)36-4-6-3-34-15-9(14(30)26(15)10(6)16(31)32)21-11(27)8(24-33-2)7-5-35-17(19)20-7;;;;;;;;;;;/h2*5,9,15H,3-4H2,1-2H3,(H2,19,20)(H,21,27)(H,23,29)(H,31,32);;;;;7*1H2/q;;4*+1;;;;;;;/p-4/b2*24-8-;;;;;;;;;;;/t2*9?,15-;;;;;;;;;;;/m11.........../s1
InChi Key
KTAVBOYXMBQFGR-PWCTXUHCSA-J
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Ceftriaxone is a cephalosporin antibiotic.1 It is selectively active against Gram-negative bacteria, including N. gonorrhea and S. pyogenes (MICs = 0.01-0.025 and 0.012-0.25 µg/ml, respectively), over Gram-positive bacteria such as S. epidermidis and S. aureus (MICs = >25 µg/ml for both). Ceftriaxone inhibits S. pyogenes penicillin-binding protein 2 (PBP2) and PBP3 (IC50s = 0.108 and 0.146 µg/ml, respectively).2 Formulations containing ceftriaxone have been used in the treatment of various bacterial infections.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Neu, H.C., Meropol, N.J., and Fu, K.P. Antibacterial activity of ceftriaxone (Ro 13-9904), a β-lactamase-stable cephalosporin. Antimicrob. Agents Chemother. 19(3), 414-423 (1981).

    2. Yan, S., Mendelman, P.M., and Stevens, D.L. The in vitro antibacterial activity of ceftriaxone against Streptococcus pyogenes is unrelated to penicillin-binding protein 4. FEMS Microbiol. Lett. 110(3), 313-317 (1993).