A KCa1.1/BK channel opener
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NS 1619

Item No. 18876

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,3-dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one
CAS Number
153587-01-0
Molecular Formula
C15H8F6N2O2
Formula Weight
362.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS(pH7.2) (1:1): 0.5 mg/mlEthanol: 30 mg/ml
λmax
211, 283 nm
SMILES
OC1=C(N2C(NC3=C2C=CC(C(F)(F)F)=C3)=O)C=C(C(F)(F)F)C=C1
InChi Code
InChI=1S/C15H8F6N2O2/c16-14(17,18)7-1-3-10-9(5-7)22-13(25)23(10)11-6-8(15(19,20)21)2-4-12(11)24/h1-6,24H,(H,22,25)
InChi Key
YLFMCMWKHSDUCT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $90

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    10 mg

    $157

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    25 mg

    $245

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    Product Description

    NS 1619 is a calcium-dependent activator of large-conductance calcium-activated potassium (KCa1.1/BK) channels in vascular smooth muscle.1 It is typically used at a concentration of 30 µM to hyperpolarize the membrane potential of single myocytes during studies of smooth muscle relaxation and vasodilation.2,3 Studies suggest that activation of KCa1.1/BK channels by NS 1619 can protect the cardiac muscle against pulmonary hypertension as well as ischemia and reperfusion injury in various animal models.4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Edwards, G., Niederste-Hollenberg, A., Schneider, J., et al. Ion channel modulation by NS 1619, the putative BKCa channel opener, in vascular smooth muscle. Br. J. Pharmacol. 113(4), 1538-1457 (1994).

    2. Yamamura, H., Ohi, Y., Muraki, K., et al. BK channel activation by NS-1619 is partially mediated by intracellular Ca2+ release in smooth muscle cells of porcine coronary artery. Br. J. Pharmacol. 132(4), 828-834 (2001).

    3. Holland, M., Langton, P.D., Standen, N.B., et al. Effects of the BKCa channel activator, NS1619, on rat cerebral artery smooth muscle. Br. J. Pharmacol. 117(1), 119-129 (1996).

    4. Revermann, M., Neofitidou, S., Kirschning, T., et al. Inhalation of the BKCa-opener NS1619 attenuates right ventricular pressure and improves oxygenation in the rat monocrotaline model of pulmonary hypertension. PLoS One 9(1), (2014).

    5. Xu, W., Liu, Y., Wang, S., et al. Cytoprotective role of Ca2+- activated K+ channels in the cardiac inner mitochondrial membrane. Science 298(5595), 1029-1033 (2002).