An antiviral useful in Alzheimer’s research
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Ro 90-7501

Item No. 18881

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2'-(4-aminophenyl)-[2,5'-bi-1H-benzimidazol]-5-amine
CAS Number
293762-45-5
Molecular Formula
C20H16N6
Formula Weight
340.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMF:PBS (pH 7.2) (1:8): 0.1 mg/mlDMSO: 10 mg/mlEthanol: 2 mg/ml
λmax
226, 276, 354 nm
SMILES
NC1=CC=C(C2=NC(C=CC(C3=NC4=C(C=CC(N)=C4)N3)=C5)=C5N2)C=C1
InChi Code
InChI=1S/C20H16N6/c21-13-4-1-11(2-5-13)19-23-15-7-3-12(9-17(15)25-19)20-24-16-8-6-14(22)10-18(16)26-20/h1-10H,21-22H2,(H,23,25)(H,24,26)
InChi Key
PAGZCEHLFCJSPV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Ro 90-7501 is a bi-benzimidazole compound that was first found to retard the formation of mature amyloid β42 fibrils in a cell-based assay.1 Instead, extended polymeric sheets and fibrillary intermediates of amyloid β42 accumulated in response to Ro 90-7501 treatment, resulting in reduced cytotoxicity (EC50 = 2 µM).1 More recently, Ro 90-7501 was shown to modulate signaling in cells stimulated with polyinosinic-polycytidylic acid (poly(I:C), a toll-like receptor 3 (TLR3), and RIG-1-like receptor agonist.2 Ro 90-7501 (10 µM) enhanced poly(I:C)-induced IFN-β expression, decreased NF-κB activation, and amplified the suppression of vesicular stomatitis virus replication by poly(I:C) in HEK293 cells expressing TLR3.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bohrmann, B., Adrian, M., Dubochet, J., et al. Self-assembly ofβamyloid 42 is retarded by small molecular ligands at the stage of structural intermediates. J. Struct. Biol. 130(2-3), 232-246 (2000).

    2. Guo, F., Mead, J., Aliya, N., et al. RO 90-7501 enhances TLR3 and RLR agonist induced antiviral response. PLoS One 7(10), (2012).