A biotinylation reagent
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Biotin-LC-LC-NHS

Item No. 18887

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3aS,4S,6aR)-N-[6-[[6-[(2,5-dioxo-1-pyrrolidinyl)oxy]-6-oxohexyl]amino]-6-oxohexyl]hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanamide
CAS Number
89889-52-1
Synonyms
  • Biotinamidohexanoyl-6-aminohexanoic Acid N-hydroxysuccinimide ester​
Molecular Formula
C26H41N5O7S
Formula Weight
567.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 25 mM
SMILES
O=C1N[C@]2([H])[C@H](CCCCC(NCCCCCC(NCCCCCC(ON3C(CCC3=O)=O)=O)=O)=O)SC[C@]2([H])N1
InChi Code
InChI=1S/C26H41N5O7S/c32-20(27-16-8-2-4-12-24(36)38-31-22(34)13-14-23(31)35)10-3-1-7-15-28-21(33)11-6-5-9-19-25-18(17-39-19)29-26(37)30-25/h18-19,25H,1-17H2,(H,27,32)(H,28,33)(H2,29,30,37)/t18-,19-,25-/m0/s1
InChi Key
ATYCFNRXENKXSE-MHPIHPPYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $36

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    10 mg

    $63

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    25 mg

    $135

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    Product Description

    Biotin-LC-LC-NHS is a biotinylation reagent that contains an N-hydroxysuccinimide (NHS) moiety, which activates carboxylic acid groups on biotin to facilitate coupling reactions, and a 30.5 Å spacer to decrease steric hindrance.1 It has been used to biotinylate small molecules such as paclitaxel (Item No. 10461) and coenzyme Q10 (Item No. 11506) for use in binding site characterization.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lis, L.G., Smart, M.A., Luchniak, A., et al. Synthesis and biological evaluation of a biotinylated paclitaxel with an extra-long chain spacer arm. ACS Med. Chem. Lett. 3(9), 745-748 (2012).

    2. Murai, M., Yamashita, T., Senoh, M., et al. Characterization of the ubiquinone binding site in the alternative NADH-quinone oxidoreductase of Saccharomyces cerevisiae by photoaffinity labeling. Biochemistry 49(13), 2973-2980 (2010).