A Ca2+-activated IK/SK potassium channel activator
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NS 309

Item No. 18889

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6,7-dichloro-1H-indole-2,3-dione 3-oxime
CAS Number
18711-16-5
Molecular Formula
C8H4Cl2N2O2
Formula Weight
231.0
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
λmax
233, 262, 313, 347 nm
SMILES
O=C1/C(C2=CC=C(Cl)C(Cl)=C2N1)=N\O
InChi Code
InChI=1S/C8H4Cl2N2O2/c9-4-2-1-3-6(5(4)10)11-8(13)7(3)12-14/h1-2,14H,(H,11,12,13)
InChi Key
CVOUSAVHMDXCKG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $54

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    10 mg

    $75

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    50 mg

    $315

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    Product Description

    NS 309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 µM for SK channels and 10-90 nM for IK channels).1,2 It can also activate voltage-gated Kv11.1 channels (hERG; IC50 = 1 µM), but does not, however, affect large conductance (BK/KCa1.1) channels.1,2,3 NS 309 can modulate neuronal firing patterns by enhancing SK-mediated hyperpolarizing effects.1,2 It is 730-fold (SK channels) and 7,400-fold (IK channels) more potent than 1-EBIO (Item No. 14575) and often used in conjunction with CyPPA (Item No. 15614) to distinguish between SK1 and SK3 subtypes.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pedarzani, P., and Stocker, M. Molecular and cellular basis of small- and intermediate-conductance, calcium-activated potassium channel function in the brain. Cell. Mol. Life Sci. 65(20), 3196-3217 (2008).

    2. Hougaard, C., Eriksen, B.L., Jorgensen, S., et al. Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+-activated K+ channels. Br. J. Pharmacol. 151(5), 655-665 (2007).

    3. Wulff, H., and Köhler, R. Endothelial small-conductance and intermediate-conductance KCa channels: An update on their pharmacology and usefulness as cardiovascular targets. J. Biomed. Sci. 61(2), 102-112 (2013).