A β-glucuronidase inhibitor
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D-Saccharic Acid 1,4-lactone (hydrate)

Item No. 18896

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,4-lactone D-glucaric acid, monohydrate
CAS Number
61278-30-6
Synonyms
  • D-Glucaro-1,4-lactone
Molecular Formula
C6H8O7 • H2O
Formula Weight
210.1
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 20 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
216 nm
SMILES
O=C1O[C@@]([C@H](O)C(O)=O)([H])[C@H](O)[C@H]1O.O
InChi Code
InChI=1S/C6H8O7.H2O/c7-1-2(8)6(12)13-4(1)3(9)5(10)11;/h1-4,7-9H,(H,10,11);1H2/t1-,2-,3+,4+;/m1./s1
InChi Key
NPFKVZHSFSFLPU-QGBSHYGGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

    $36

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    250 mg

    $77

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    500 mg

    $120

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    1 g

    $219

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    Product Description

    D-Saccharic acid 1,4-lactone is an inhibitor of β-glucuronidase (IC50 = 45 µM for the human enzyme).1 It is commonly used as a standard in the development of novel inhibitors of β-glucuronidase.1,2 D-Saccharic acid 1,4-lactone is also used to prevent the cleavage of glucuronides in plasma, serum, or urine by β-glucuronidase in samples.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Khan, K.M., Saad, S.M., Shaikh, N.N., et al. Synthesis and β-glucuronidase inhibitory activity of 2-arylquinazolin-4(3H)-ones. Bioorg. Med. Chem. 22(13), 3449-3454 (2014).

    2. Jamil, W., Perveen, S., Shah, S.A.A., et al. Phenoxyacetohydrazide Schiff bases: β-Glucuronidase inhibitors. Molecules 19(7), 8788-8802 (2014).

    3. Lu, Q.Y., Zhang, L., Eibl, G., et al. Overestimation of flavonoid aglycones as a result of the ex vivo deconjugation of glucuronides by the tissue β-glucuronidase. J. Pharm. Biomed. Anal. 88, 364-369 (2014).