RB394

RB394 is an orally bioavailable, dual modulator of soluble epoxide hydrolase (sEH) and PPARγ that inhibits sEH with an IC₅₀ of 0.33 µM and activates PPARγ with an EC₅₀ of 0.3 µM.¹ It is inactive at PPARδ and shows 29% activation of PPARα, relative to control, at 10 µM.¹ RB394 is water soluble, orally bioavailable, and can be delivered through drinking water. In a two week in vivo pharmacokinetic study in mice, 30 mg/kg body weight in drinking water resulted in a final plasma concentration of ~3 µM.¹ This coincided with upregulation of PPARγ target genes, as well as PPARα and PPARδ, in mouse livers.¹

WARNING This product is not for human or veterinary use.

1. Blöcher, R., Lamers, C., Wittman, S.K., et al. N-benzylbenzamides: A novel merged scaffold for orally available dual soluble epoxide hydrolase/peroxisome proliferator-activated receptor γ modulators. J. Med. Chem. 59(1), 61-81 (2016).