An inhibitor of LDH
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Sodium Oxamate

Item No. 19057

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-amino-2-oxo-acetic acid, monosodium salt
CAS Number
565-73-1
Synonyms
  • Oxalic Acid monoamide
  • Oxamic Acid
Molecular Formula
C2H2NO3 • Na
Formula Weight
111.0
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
SMILES
[O-]C(C(N)=O)=O.[Na+]
InChi Code
InChI=1S/C2H3NO3.Na/c3-1(4)2(5)6;/h(H2,3,4)(H,5,6);/q;+1/p-1
InChi Key
RQVZIJIQDCGIKI-UHFFFAOYSA-M
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

    $65

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    10 g

    $106

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    25 g

    $186

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    50 g

    $340

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    Cayman Chemical
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    Product Description

    Sodium oxamate is a derivative of pyruvate that inhibits the conversion of pyruvate to lactate via lactate dehydrogenase, thus disrupting glycolysis.1 Because cancer cells produce a large amount of energy via aerobic glycolysis, sodium oxamate has been studied as an inhibitor of carbohydrate metabolism in various tumors.2,3,4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Novoa, W.B., Winer, A.D., Glaid, A.J., et al. Lactic dehydrogenase. V. Inhibition by oxamate and by oxalate. The Journal of Biological Chemisty 234(5), 1143-1148 (1959).

    2. Yang, Y., Su, D., Zhao, L., et al. Different effects of LDH-A inhibition by oxamate in non-small cell lung cancer cells. Oncotarget 5(23), 11886-11896 (2014).

    3. Zub, K.A., de Sousa, M.M.L., Sarno, A., et al. Modulation of cell metabolic pathways and oxidative stress signaling contribute to acquired melphalan resistance in multiple myeloma cells. PLoS One 10(3), e0119857 (2015).

    4. Cui, J., Shi, M., Xie, D., et al. FOXM1 promotes the warburg effect and pancreatic cancer progression via transactivation of LDHA expression. Clin. Cancer Res. 20(10), 2595-2606 (2014).

    5. Zhao, Z., Han, F., Yang, S., et al. Oxamate-mediated inhibition of lactate dehydrogenase induces protective autophagy in gastric cancer cells: Involvement of the Akt-mTOR signaling pathway. Cancer Lett. 358(1), 17-26 (2015).