A general PTP inhibitor
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PTP Inhibitor III

Item No. 19059

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[4-(2-bromoacetyl)phenoxy]-acetic acid
CAS Number
29936-81-0
Synonyms
  • α-Bromo-4-(carboxymethoxy)acetophenone
  • Protein Tyrosine Phosphatase Inhibitor III
Molecular Formula
C10H9BrO4
Formula Weight
273.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 25 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 0.5 mg/ml
λmax
221, 281 nm
SMILES
O=C(CBr)C1=CC=C(OCC(O)=O)C=C1
InChi Code
InChI=1S/C10H9BrO4/c11-5-9(12)7-1-3-8(4-2-7)15-6-10(13)14/h1-4H,5-6H2,(H,13,14)
InChi Key
RLSUZPAAQRBGTM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    1 mg

    $40

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    5 mg

    $180

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    10 mg

    $263

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    Product Description

    PTP Inhibitor III is an α-haloacetophenone derivative that acts as a photoreversible covalent inhibitor of protein tyrosine phosphatases (PTPs).1 It binds the catalytic domain of SHP-1 (Ki = 184 µM) and covalently reacts with free thiols, a reaction that is reversible with irradiation (350 nm). PTP Inhibitor III is cell permeable and inhibits a broad range of PTPs.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Arabaci, G., Guo, X.-C., Beebe, K.D., et al. α-Haloacetophenone derivatives as photoreversible covalent inhibitors of protein tyrosine phosphatases. J. Am. Chem. Soc. 121(21), 5085-5086 (1999).

    2. Kanda, M., Ihara, Y., Murata, H., et al. Glutaredoxin modulates platelet-derived growth factor-dependent cell signaling by regulating the redox status of low molecular weight protein-tyrosine phosphatase. The Journal of Biological Chemisty 281(39), 28518-28528 (2006).