A potent heme oxygenase inhibitor
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Tin Mesoporphyrin IX (chloride)

Item No. 19071

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(OC-6-13)-dichloro[7,12-diethyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-κN21,κN22,κN23,κN24]-stannate(2-), dihydrogen
CAS Number
106344-20-1
Synonyms
  • NSC 267099
  • SnMP
Molecular Formula
C34H34Cl2N4O4Sn • 2H
Formula Weight
754.3
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 0.5 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
λmax
399 nm
SMILES
[Cl-][Sn+4]1([N-]2C3=CC(C(C)=C4CCC([O-])=O)=[N]1C4=CC5=C6CCC([O-])=O)([N](C7=C8)=C(C(C)=C7CC)C=C2C(CC)=C3C)([N-]5C8=C6C)[Cl-].[H+].[H+]
InChi Code
InChI=1S/C34H38N4O4.2ClH.Sn/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;;;/h13-16H,7-12H2,1-6H3,(H4,35,36,37,38,39,40,41,42);2*1H;/q;;;+4/p-4/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;;;
InChi Key
LLDZJTIZVZFNCM-UHEVNVKKSA-J
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Tin mesoporphyrin IX is a potent, competitive inhibitor of HO activity in vitro (Ki = 14 nM).1 It inhibits hepatic, renal, and splenic HO activity in vivo for extended periods of time.1 Tin mesoporphyrin IX blocks bilirubin production in vivo, decreasing HO activity in animal models of hyperbilirubinemia.1,2,3 Tin mesoporphyrin IX can be used to study the physiological roles of induced HO-1 expression in animal models.4,5,6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Drummond, G.S., Galbraith, R.A., Sardana, M.K., et al. Reduction of the C2 and C4 vinyl groups of Sn-protoporphyrin to form Sn-mesoporphyrin markedly enhances the ability of the metalloporphyrin to inhibit in vivo heme catabolism. Arch. Biochem. Biophys. 255(1), 64-74 (1987).

    2. Drummond, G.S., and Kappas, A. Prevention of neonatal hyperbilirubinemia by tin protoporphyrin IX, a potent competitive inhibitor of heme oxidation. Proc. Natl. Acad. Sci. USA 78(10), 6466-6470 (1981).

    3. Hamori, C.J., Vreman, H.J., and Stevenson, D.K. Suppression of carbon monoxide excretion by zinc mesoporphyrin in adult Wistar rats: Evidence for potent in vivo inhibition of bilirubin production. Res. Commun. Chem. Pathol. Pharmacol. 62(1), 41-48 (1988).

    4. Chen, T.m., Li, J., Fan, L., et al. Effects of heme oxygenase-1 upregulation on blood pressure and cardiac function in an animal model of hypertensive myocardial infarction. Int. J. Mol. Sci. 14(2), 2684-2706 (2013).

    5. Koeppen, A.H., Dickson, A.C., and Smith, J. Heme oxygenase in experimental intracerebral hemorrhage: the benefit of tin-mesoporphyrin. J. Neuropathol. Exp. Neurol. 63(6), 587-597 (2004).

    6. Zhang, L., Gan, Z.K., Han, L.N., et al. Protective effect of heme oxygenase-1 on Wistar rats with heart failure through the inhibition of inflammation and amelioration of intestinal microcirculation. J.Geriatr.Cardiol. 12(4), 353-365 (2015).