A protein phosphatase inhibitor
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Cantharidic Acid (sodium salt)

Item No. 19073

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1R,2S,3R,4S)-rel-2,3-dimethyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid, disodium salt
CAS Number
1465-77-6
Molecular Formula
C10H12O5 • 2Na
Formula Weight
258.2
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 2 mg/ml
SMILES
[O-]C([C@@]1(C)[C@](C([O-])=O)(C)[C@@H]2CC[C@H]1O2)=O.[Na+].[Na+]
InChi Code
InChI=1S/C10H14O5.2Na/c1-9(7(11)12)5-3-4-6(15-5)10(9,2)8(13)14;;/h5-6H,3-4H2,1-2H3,(H,11,12)(H,13,14);;/q;2*+1/p-2/t5-,6+,9+,10-;;
InChi Key
JFALSOLNDKMHAL-CSYCBQNYSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $49

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    10 mg

    $77

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    25 mg

    $178

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    50 mg

    $306

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    Product Description

    Cantharidic acid is a hydrolysis product of cantharidin (Item No. 14589), an inhibitor of protein phosphatases first isolated from Chinese blister beetles.1 Cantharidic acid inhibits the protein phosphatases PP1 and PP2A with IC50 values of 0.6 and 0.05 µM, respectively, but does not affect PP2B or PP2C.1 Cantharidic acid is frequently used to study cellular processes that are regulated by reversible protein phosphorylation.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. McCluskey, A., Sim, A.T.R., and Sakoff, J.A. Serine-threonine protein phosphatase inhibitors: Development of potential therapeutic strategies. J. Med. Chem. 45(6), 1151-1175 (2002).