An allosteric ligand of Frizzled4
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FzM1

Item No. 19074

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[3-hydroxy-5-(2-thienyl)phenyl]-N'-2-naphthalenyl-urea
CAS Number
1680196-54-6
Synonyms
  • Frizzled M1
Molecular Formula
C21H16N2O2S
Formula Weight
360.4
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 12 mg/mlDMF:PBS (pH 7.2)(1:3): 0.2 mg/mlDMSO: 10 mg/ml
λmax
211, 233, 261, 284 nm
SMILES
O=C(NC1=CC(O)=CC(C2=CC=CS2)=C1)NC3=CC4=CC=CC=C4C=C3
InChi Code
InChI=1S/C21H16N2O2S/c24-19-12-16(20-6-3-9-26-20)11-18(13-19)23-21(25)22-17-8-7-14-4-1-2-5-15(14)10-17/h1-13,24H,(H2,22,23,25)
InChi Key
OBTSACXGWYGCPK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

    $41

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    1 mg

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    5 mg

    $130

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    Cayman Chemical
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    Product Description

    Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis.1,2,3 Wnt proteins initiate cell signaling by binding Frizzled (Fz) receptors, a family of G protein-coupled receptors. FzM1 is an allosteric ligand of Fz4.4 At 10 µM, it inhibits nuclear translocation of β-catenin in U87MG glioma cells treated with lithium chloride, a GSK3 inhibitor that enhances the Wnt canonical signaling pathway.4 FzM1 impairs the ability of U87MG cells to form neurospheres in culture and stimulates the differentiation of Caco-2 epithelial colorectal adenocarcinoma cells.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Clevers, H. Wnt/β-catenin signaling in development and disease. Cell 127(3), 469-480 (2006).

    2. Polakis, P. Wnt signaling and cancer. Genes Dev. 14(15), 1837-1851 (2000).

    3. Reya, T., and Clevers, H. Wnt signalling in stem cells and cancer. Nature 434(7035), 834-850 (2005).

    4. Generoso, S.F., Giustinano, M., La Regina, G., et al. Pharmacological folding chaperones act as allosteric ligands of Frizzled4. Nat. Chem. Biol. 11(4), 280-286 (2016).