A toxin from rattlesnake venom
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Product Type

Proteins

Research Area

Cell Biology
ECM & Adhesion Molecules

Convulxin

Item No. 19082

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
37206-04-5
MW
~84 kDa
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
HEPES Buffer: Soluble
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    50 µg

    $1,044

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    Product Description

    Convulxin is a toxin that was first isolated from rattlesnake venom. It activates the collagen receptor glycoprotein VI (GPVI) on platelets and initiates blood clotting.1,2 Convulxin is used to study signaling through GPVI and to characterize platelet function.3,4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Vargaftig, B.B., Prado-Francheschi, J., Chignard, M., et al. Activation of guinea-pig platelets induced by convulxin, a substance extracted from the venom of Crotalus durissus cascavella. Eur. J. Pharmacol. 68(4), 451-464 (2016).

    2. Jandrot-Perrus, M., Lagrue, A.H., Okuma, M., et al. Adhesion and activation of human platelets induced by convulxin involve glycoprotein VI and integrin α2β1. The Journal of Biological Chemisty 272(43), 27035-27041 (1997).

    3. Chatterjee, M.S., Denney, W.S., Jing, H., et al. Systems biology of coagulation initiation: Kinetics of thrombin generation in resting and activated human blood. PLoS Comput. Biol. 6(9), (2010).

    4. Casari, C., Berrou, E., Lebret, M., et al. von Willebrand factor mutation promotes thrombocytopathy by inhibiting integrin αIIbβ3. J. Clin. Invest. 123(12), 5071-5081 (2013).

    5. van Bladel, E.R., Laarhoven, A.G., van der Heijden, L.B., et al. Functional platelet defects in children with severe chronic ITP as tested with 2 novel assays applicable for low platelet counts. Blood 123(10), 1556-1563 (2014).