An inhibitor of NF-κB activation
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NF-κB Activation Inhibitor III

Item No. 19083

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-chloro-4-nitro-N-(5-nitro-2-thiazolyl)-benzamide
CAS Number
380623-76-7
Synonyms
  • SM-7368
Molecular Formula
C10H5ClN4O5S
Formula Weight
328.7
Purity
≥99%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
ClC1=C([N+]([O-])=O)C=CC(C(NC2=NC=C([N+]([O-])=O)S2)=O)=C1
InChi Code
InChI=1S/C10H5ClN4O5S/c11-6-3-5(1-2-7(6)14(17)18)9(16)13-10-12-4-8(21-10)15(19)20/h1-4H,(H,12,13,16)
InChi Key
XCHLNGBTHLJLFG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $98

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    25 mg

    $412

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    Cayman Chemical
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    Product Description

    NF-κB activation inhibitor III is an inhibitor of NF-κB activation.1 NF-κB activation inhibitor III (20 µM) inhibits TNF-α-induced NF-κB activation in HT-1080 fibrosarcoma cells.1 NF-κB activation inhibitor III inhibits TNF-α-induced expression of the gene encoding matrix metalloproteinase-9 (MMP-9) in HT-1080 cells in a concentration-dependent manner and decreases TNF-α-induced migration of HT-1080 cells. It inhibits IL-6 release induced by TNF-α from primary rat brain pericytes when used at concentrations of 1, 5, and 10 µM.2 NF-κB activation inhibitor III (5 µM) increases IL-8 secretion in HT-29 and Caco-2 colon cancer cells when used in combination with glyoxal.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lee, H.Y., Park, K.S., Kim, M.K., et al. A small compound that inhibits tumor necrosis factor-α-induced matrix metalloproteinase-9 upregulation. Biochem. Biophys. Res. Commun. 336(2), 716-722 (2005).

    2. Matsumoto, J., Dohgu, S., Takata, F., et al. TNF-α-sensitive brain pericytes activate microglia by releasing IL-6 through cooperation between IκB-NFκB and JAK-STAT3 pathways. Brain Res. 1692, 34-44 (2018).

    3. Kuntz, S., Kunz, C., and Rudloff, S. Carbonyl compounds methylglyoxal and glyoxal affect interleukin-8 secretion in intestinal cells by superoxide anion generation and activation of MAPK p38. Mol. Nutr. Food Res. 54(10), 1458-1467 (2010).