NF-κB Activation Inhibitor III

NF-κB activation inhibitor III is an inhibitor of NF-κB activation.¹ NF-κB activation inhibitor III (20 µM) inhibits TNF-α-induced NF-κB activation in HT-1080 fibrosarcoma cells.¹ NF-κB activation inhibitor III inhibits TNF-α-induced expression of the gene encoding matrix metalloproteinase-9 (MMP-9) in HT-1080 cells in a concentration-dependent manner and decreases TNF-α-induced migration of HT-1080 cells. It inhibits IL-6 release induced by TNF-α from primary rat brain pericytes when used at concentrations of 1, 5, and 10 µM.² NF-κB activation inhibitor III (5 µM) increases IL-8 secretion in HT-29 and Caco-2 colon cancer cells when used in combination with glyoxal.³

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1. Lee, H.Y., Park, K.S., Kim, M.K., et al. A small compound that inhibits tumor necrosis factor-α-induced matrix metalloproteinase-9 upregulation. Biochem. Biophys. Res. Commun. 336(2), 716-722 (2005).

2. Matsumoto, J., Dohgu, S., Takata, F., et al. TNF-α-sensitive brain pericytes activate microglia by releasing IL-6 through cooperation between IκB-NFκB and JAK-STAT3 pathways. Brain Res. 1692, 34-44 (2018).

3. Kuntz, S., Kunz, C., and Rudloff, S. Carbonyl compounds methylglyoxal and glyoxal affect interleukin-8 secretion in intestinal cells by superoxide anion generation and activation of MAPK p38. Mol. Nutr. Food Res. 54(10), 1458-1467 (2010).