An NR2A-selective NMDA receptor antagonist
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TCN 201

Item No. 19086

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[[(3-chloro-4-fluorophenyl)sulfonyl]amino]methyl]-benzoic acid, 2-benzoylhydrazide
CAS Number
852918-02-6
Molecular Formula
C21H17ClFN3O4S
Formula Weight
461.9
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMF:PBS (pH7.2) (1:40): 0.02 mg/mlDMSO: 20 mg/ml
λmax
232 nm
SMILES
O=C(NNC(C1=CC=C(CNS(C2=CC(Cl)=C(F)C=C2)(=O)=O)C=C1)=O)C3=CC=CC=C3
InChi Code
InChI=1S/C21H17ClFN3O4S/c22-18-12-17(10-11-19(18)23)31(29,30)24-13-14-6-8-16(9-7-14)21(28)26-25-20(27)15-4-2-1-3-5-15/h1-12,24H,13H2,(H,25,27)(H,26,28)
InChi Key
FYIBXBFDXNPBSF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $44

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    5 mg

    $130

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    10 mg

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    Product Description

    TCN 201 is a selective antagonist of NMDA receptors containing the NR2A subunit (pIC50s = 6.8 and <4.3 for human recombinant NR2A and NR2B, respectively).1 It has been shown to bind to a novel allosteric site located at the dimer interface between the GluN1 and GluN2 binding domains, thereby reducing glycine signal transduction and inhibiting NMDA receptor function.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bettini, E., Sava, A., Griffante, C., et al. Identification and characterization of novel NMDA receptor antagonists selective for NR2A- over NR2B-containing receptors. J. Pharmacol. Exp. Ther. 335(3), 636-644 (2010).

    2. Hansen, K.B., Ogden, K.K., and Traynelis, S.F. Subunit-selective allosteric inhibition of glycine binding to NMDA receptors. J. Neurosci. 32(18), 6197-6208 (2012).