A positive modulator of Wnt signaling
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Product Categories

Product Type

Biochemicals

Research Area

Cell Biology
Cell Signaling
Wnt Signaling

HLY78

Item No. 19087

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-ethyl-5,6-dihydro-5-methyl-[1,3]dioxolo[4,5-j]phenanthridine
CAS Number
854847-61-3
Molecular Formula
C17H17NO2
Formula Weight
267.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 12 mg/mlDMF:PBS (pH 7.2) (1:5): 0.2 mg/mlDMSO: 2 mg/mlEthanol: 2 mg/ml
λmax
214, 282, 319 nm
SMILES
CCC1=CC=CC2=C1N(C)CC3=CC4=C(OCO4)C=C32
InChi Code
InChI=1S/C17H17NO2/c1-3-11-5-4-6-13-14-8-16-15(19-10-20-16)7-12(14)9-18(2)17(11)13/h4-8H,3,9-10H2,1-2H3
InChi Key
FAZZYPIBZBGQSH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

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    Product Description

    HLY78 is a positive modulator of the Wnt/β-catenin pathway, as it augments Wnt-mediated signaling in cells at concentrations of 5 to 20 µM.1 It has no significant effect alone, and it does not affect LiCl-stimulated β-catenin signaling. A biotinylated form of HLY78 binds Axin at its DIX domain, which is thought to potentiate Axin-LRP6 association.1 HLY78 activates Wnt signaling in vivo, altering Wnt-dependent gene expression and embryonic development in zebrafish.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, S., Yin, J., Chen, D., et al. Small-molecule modulation of Wnt signaling via modulating the Axin-LRP5/6 interaction. Nat. Chem. Biol. 9, 579-585 (2013).