Induces apoptosis by blocking Survivin/Ran interactions
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Product Categories

Product Type

Biochemicals

Research Area

Cancer
Cancer Stem Cell Research
Cell Death
Apoptosis

LLP-3

Item No. 19088

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[3,5-bis(phenylmethoxy)phenyl]-6-(5-chloro-2-hydroxyphenyl)-1,2-dihydro-2-oxo-3-pyridinecarbonitrile
CAS Number
1453835-43-2
Molecular Formula
C32H23ClN2O4
Formula Weight
535.0
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMF:PBS(pH7.2) (1:2): 0.3 mg/mlDMSO: 2 mg/ml
λmax
372 nm
SMILES
O=C1NC(C2=C(O)C=CC(Cl)=C2)=CC(C3=CC(OCC4=CC=CC=C4)=CC(OCC5=CC=CC=C5)=C3)=C1C#N
InChi Code
InChI=1S/C32H23ClN2O4/c33-24-11-12-31(36)28(15-24)30-17-27(29(18-34)32(37)35-30)23-13-25(38-19-21-7-3-1-4-8-21)16-26(14-23)39-20-22-9-5-2-6-10-22/h1-17,36H,19-20H2,(H,35,37)
InChi Key
NZRBRJQYGLEINZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    LLP-3 is a cell-permeable ligand of Survivin that blocks its interaction with Ran, resulting in the induction of apoptosis (IAP) in glioma stem cells (IC50 = 31 µM).1 It abolishes the growth of glioblastoma multiforme cell in spheres and in tumor slice cultures.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Guvenc, H., Pavlyukov, M.S., Joshi, K., et al. Impairment of glioma stem cell survival and growth by a novel inhibitor for Survivin-Ran protein complex. Clin. Cancer Res. 19(3), 631-642 (2013).