A selective FASN inhibitor
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GSK837149A

Item No. 19098

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,4'-(carbonyldiimino)bis[N-(4-methyl-2-pyrimidinyl)-benzenesulfonamide
CAS Number
13616-29-0
Molecular Formula
C23H22N8O5S2
Formula Weight
554.6
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 5 mg/ml
λmax
288 nm
SMILES
CC1=CC=NC(NS(C2=CC=C(NC(NC3=CC=C(S(NC4=NC=CC(C)=N4)(=O)=O)C=C3)=O)C=C2)(=O)=O)=N1
InChi Code
InChI=1S/C23H22N8O5S2/c1-15-11-13-24-21(26-15)30-37(33,34)19-7-3-17(4-8-19)28-23(32)29-18-5-9-20(10-6-18)38(35,36)31-22-25-14-12-16(2)27-22/h3-14H,1-2H3,(H,24,26,30)(H,25,27,31)(H2,28,29,32)
InChi Key
RSINKZJTTORDAJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $153

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    10 mg

    $268

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    25 mg

    $587

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    Product Description

    GSK837149A is a selective, reversible inhibitor of FASN (IC50 = 15.8 nM).1 It acts by inhibiting the β-ketoacyl reductase activity of FASN.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Vázquez, M.J., Leavens, W., Liu, R., et al. Discovery of GSK837149A, an inhibitor of human fatty acid synthase targeting the β-ketoacyl reductase reaction. FEBS J. 275(7), 1556-1567 (2008).