An inhibitor of Na+/H+ exchangers
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5-(N,N-dimethyl)-Amiloride (hydrochloride)

Item No. 19100

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-amino-N-(aminoiminomethyl)-6-chloro-5-(dimethylamino)-2-pyrazinecarboxamide, monohydrochloride
CAS Number
2235-97-4
Synonyms
  • DMA
  • L-591,605
  • MK-685
Molecular Formula
C8H12ClN7O • HCl
Formula Weight
294.1
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
λmax
231, 294, 374 nm
SMILES
CN(C)C1=NC(N)=C(C(NC(N)=N)=O)N=C1Cl.Cl
InChi Code
InChI=1S/C8H12ClN7O.ClH/c1-16(2)6-4(9)13-3(5(10)14-6)7(17)15-8(11)12;/h1-2H3,(H2,10,14)(H4,11,12,15,17);1H
InChi Key
IIUPTHVVXMBJMQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    Product Description

    Sodium-hydrogen exchangers (NHE) are involved in maintaining sodium and pH balance in a variety of tissues. They are also known as sodium-hydrogen antiporters and solute carrier family 9 members. 5-(N,N-dimethyl)-Amiloride (DMA) inhibits NHE1, NHE2, and NHE3 with Ki values of 0.02, 0.25, and 14 μM, respectively.1 Because NHE1 is present in dorsal root ganglion and spinal cord, DMA was investigated for its ability to reduce inflammatory pain in rat nociception behavior tests.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Masereel, B., Pochet, L., and Laeckmann, D. An overview of inhibitors of Na+/H+ exchanger. Eur. J. Med. Chem. 38(6), 547-554 (2003).

    2. Rocha-González, H.I., Castadeñeda-Corral, G., Araiza-Saldaña, C.I., et al. Identification of the Na+/H+ exchanger 1 in dorsal root ganglion and spinal cord: Its possible role in inflammatory nociception. Neuroscience 160(1), 156-164 (2009).