An inhibitor of c-Myc and v-Myc interaction with Max
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KJ Pyr 9

Item No. 19116

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[2-(2-furanyl)-6-(4-nitrophenyl)-4-pyridinyl]-benzamide
CAS Number
581073-80-5
Molecular Formula
C22H15N3O4
Formula Weight
385.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS(pH7.2) (1:2): 0.3 mg/mlDMSO: 20 mg/ml
λmax
280, 345 nm
SMILES
NC(C(C=C1)=CC=C1C2=CC(C3=CC=CO3)=NC(C4=CC=C([N+]([O-])=O)C=C4)=C2)=O
InChi Code
InChI=1S/C22H15N3O4/c23-22(26)16-5-3-14(4-6-16)17-12-19(15-7-9-18(10-8-15)25(27)28)24-20(13-17)21-2-1-11-29-21/h1-13H,(H2,23,26)
InChi Key
GTTDVYCKFQYVNN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $103

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    10 mg

    $135

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    25 mg

    $294

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    Cayman Chemical
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    Product Description

    KJ Pyr 9 is a cell-permeable inhibitor of c-Myc (Kd = 6.5 nM) that interferes with Myc-Max complex formation in cells.1,2 It preferentially blocks the proliferation of c-Myc-overexpressing cells, reducing Myc-driven gene expression.1 KJ Pyr 9 also potently blocks cell growth directed by overexpression of v-Myc, while less effectively blocking N-Myc- and L-Myc-dependent proliferation.2 It is effective in vivo, reducing the growth of breast cancer MDA-MB-231 xenografts in mice.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hart, J.A., Garner, A.L., Yu, J., et al. Inhibitor of MYC identified in a Kröhnke pyridine library. Proc. Natl. Acad. Sci. USA 111(34), 12556-12561 (2014).

    2. Raffeiner, P., Röck, R., Schraffl, A., et al. In vivo quantification and perturbation of Myc-Max interactions and the impact on oncogenic potential. Oncotarget 5(19), 8869-8878 (2014).