A stearoyl-CoA desaturase 1 inhibitor
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A-939572

Item No. 19123

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(2-chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-piperidinecarboxamide
CAS Number
1032229-33-6
Synonyms
  • SCD1 Inhibitor
  • Stearoyl-CoA Desaturase 1 Inhibitor
Molecular Formula
C20H22ClN3O3
Formula Weight
387.9
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 10 mg/mlEthanol: 0.5 mg/ml
λmax
224 nm
SMILES
ClC1=CC=CC=C1OC2CCN(C(NC3=CC(C(NC)=O)=CC=C3)=O)CC2
InChi Code
InChI=1S/C20H22ClN3O3/c1-22-19(25)14-5-4-6-15(13-14)23-20(26)24-11-9-16(10-12-24)27-18-8-3-2-7-17(18)21/h2-8,13,16H,9-12H2,1H3,(H,22,25)(H,23,26)
InChi Key
DPYTYQFYDLYWHZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    50 mg

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    Cayman Chemical
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    Product Description

    A-939572 inhibits stearoyl-CoA desaturase 1 (IC50 = 6.3 nM), a key enzyme for lipid metabolism that is expressed in human pluripotent stem cells (hPSCs).1 This compound has been used to induce cell death of hPSCs as well as to inhibit the proliferation of human non-small cell lung carcinoma H1299 cells in vitro.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Roongta, U.V., Pabalan, J.G., Wang, X., et al. Cancer cell dependence on unsaturated fatty acids implicates stearoyl-CoA desaturase as a target for cancer therapy. Mol. Cancer Res. 9(11), 1551-1561 (2011).

    2. Ben-David, U., Gan, Q.F., Golan-Lev, T., et al. Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen. Cell Stem Cell 12(2), 167-179 (2013).