An inhibitor of Aβ oligomerization
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NQTrp

Item No. 19127

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(1,4-dihydro-1,4-dioxo-2-naphthalenyl)-L-tryptophan
CAS Number
185351-19-3
Synonyms
  • 1,4-Naphthoquinon-2-yl-L-tryptophan
Molecular Formula
C21H16N2O4
Formula Weight
360.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 20 mg/mlEthanol: 1 mg/ml
λmax
220, 269, 446 nm
SMILES
O=C(C=C(N[C@H](C(O)=O)CC1=CNC2=C1C=CC=C2)C3=O)C4=C3C=CC=C4
InChi Code
InChI=1S/C21H16N2O4/c24-19-10-17(20(25)15-7-2-1-6-14(15)19)23-18(21(26)27)9-12-11-22-16-8-4-3-5-13(12)16/h1-8,10-11,18,22-23H,9H2,(H,26,27)/t18-/m0/s1
InChi Key
DZZUYZXINNHEGM-SFHVURJKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $28

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    5 mg

    $104

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    10 mg

    $154

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    25 mg

    $351

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    Product Description

    NQTrp is an inhibitor of Alzheimer’s disease-associated amyloid β (Aβ) oligomerization and fibrillization (IC50 = 50 nM for formation of fibrils from Aβ1-42).1,2 It has been shown to reduce the cytotoxic effect of Aβ oligomers in a cultured neuronal cell line.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Scherzer-Attali, R., Pellarin, R., Convertino, M., et al. Complete phenotypic recovery of an Alzheimer’s disease model by a quinone-tryptophan hybrid aggregation inhibitor. PLoS One 5(6), (2010).

    2. Zhang, T., Xu, W., Mu, Y., et al. Atomic and dynamic insights into the beneficial effect of the 1,4-naphthoquinon-2-yl-L-tryptophan inhibitor on Alzheimer’s Aβ1-42 dimer in terms of aggregation and toxicity. ACS Chem. Neurosci. 5(2), 148-159 (2016).