A PD-1/PD-L1 interaction inhibitor

Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC Questionnaire Download WB Questionnaire

First Name

Last Name

Institution

Country

State

Telephone (optional)

Product Name (optional)

Catalog Number (optional)

Batch Number (optional)

Message(0 / 2000)

Add an attachment (max size ~5mb) (optional)

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Product Categories

Product Type

Biochemicals

Research Area

Cancer

Immunology

PD-1/PD-L1 Inhibitor 2

Name: PD-1/PD-L1 Inhibitor 2
Brand: -

Item No. 19132

PD-1/PD-L1 Inhibitor 2 (Programmed Cell Death 1/Programmed Cell Death-Ligand 1 Inhibitor 2, CAS Number: 1675203-84-5)

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)

Technical Information

Formal Name

N-[2-[[[2-methoxy-6-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]-3-pyridinyl]methyl]amino]ethyl]-acetamide

CAS Number

1675203-84-5

Synonyms

Programmed Cell Death 1/Programmed Cell Death-Ligand 1 Inhibitor 2

Molecular Formula

C₂₅H₂₉N₃O₃

Formula Weight

419.5

Purity

≥98%

Formulation (Request formulation change)

A crystalline solid

Solubility(Learn about Variance in Solubility)

DMF: 10 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 2 mg/mlEthanol: 5 mg/ml

λ_max

281 nm

SMILES

CC1=C(COC2=CC=C(CNCCNC(C)=O)C(OC)=N2)C=CC=C1C3=CC=CC=C3

InChi Code

InChI=1S/C25H29N3O3/c1-18-22(10-7-11-23(18)20-8-5-4-6-9-20)17-31-24-13-12-21(25(28-24)30-3)16-26-14-15-27-19(2)29/h4-13,26H,14-17H2,1-3H3,(H,27,29)

InChi Key

JEDPSOYOYVELLZ-UHFFFAOYSA-N

Shipping & Storage Information

Storage

-20°C

Shipping

Room temperature in continental US; may vary elsewhere

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

1 mg

$49

Add

5 mg

$190

Add

10 mg

$354

Add

25 mg

$634

Add

Visit Our Cancer Resource Center

Find Tools & Resources to Study the Hallmarks of Cancer

Cancer cell signaling & regulation
Cancer metabolism
Tumor microenvironment

EXPLORE NOW

Product Description

The programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) interaction plays a dominant role in the suppression of T cell responses, especially in a tumor microenvironment, protecting tumor cells from lysis.¹ PD-1/PD-L1 inhibitor 2 is reported to prevent the interaction of PD-L1 with PD-1 with an IC₅₀ value of 18 nM.²

WARNING This product is not for human or veterinary use.

References & Product Citations

Product Description References

1. Pardoll, D.M. The blockade of immune checkpoints in cancer immunotherapy. Nat. Rev. Cancer 12(4), 252-264 (2012).

2. Chupak, L.S., and Zheng, X. Compounds useful as immunomodulators. PCT/US2014/053695, (2015).

Cart Subtotal:$0