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VR23

Item № 19133
CAS № 1624602-30-7
Purity ≥98%
product image
                (CAS 1624602-30-7)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $28.00 0.00
     5 mg $126.00 0.00
     10 mg $224.00 0.00
     25 mg $455.00 0.00

Pricing updated 2019-07-18. Prices are subject to change without notice.

Description

VR23 is a chloroquine (Item No. 14194) derivative that functions as a proteasome inhibitor (IC50s = 1 nM, 50-100 nM, and 3 µM for trypsin-like, chymotrypsin-like, and caspase-like proteasomes, respectively).1 It also deregulates the activity of cyclin E and other centrosomal proteins, resulting in the induction of multiple centrosome amplification, abnormal spindle formation, uneven cytokinesis, irreversible mitotic arrest, and eventually apoptosis that is specific to cancer cells.1 In combination with the chymotrypsin-like proteasome inhibitor bortezomib (Item No. 10008822), VR23 can produce a synergistic effect in killing multiple myeloma cells, including those that are resistant to bortezomib.1

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Technical Information
Formal Name
7-chloro-4-[4-[(2,4-dinitrophenyl)sulfonyl]-1-piperazinyl]-quinoline
CAS Number
1624602-30-7
Molecular Formula
C19H16ClN5O6S
Formula Weight
477.9
Purity
≥98%
Formulation
A crystalline solid
λmax
225, 307 nm
SMILES
ClC1=CC2=C(C=C1)C(N3CCN(S(C4=CC=C([N+]([O-])=O)C=C4[N+]([O-])=O)(=O)=O)CC3)=CC=N2
InChI Code
InChI=1S/C19H16ClN5O6S/c20-13-1-3-15-16(11-13)21-6-5-17(15)22-7-9-23(10-8-22)32(30,31)19-4-2-14(24(26)27)12-18(19)25(28)29/h1-6,11-12H,7-10H2
InChI Key
PDQVZPPIHADUOO-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
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Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

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References & Product Citations
Product Description References

1. Pundir, S., Vu, H.Y., Solomon, V.R., et al. VR23: A quinoline-sulfonyl hybrid proteasome inhibitor that selectively kills cancer via cyclin E-mediated centrosome amplification Cancer Research 75(19), 4164-4175 (2015).

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