A proteasome inhibitor
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VR23

Item No. 19133

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-chloro-4-[4-[(2,4-dinitrophenyl)sulfonyl]-1-piperazinyl]-quinoline
CAS Number
1624602-30-7
Molecular Formula
C19H16ClN5O6S
Formula Weight
477.9
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMF:PBS(pH7.2) (1:2): 0.3 mg/mlDMSO: 0.5 mg/ml
λmax
225, 307 nm
SMILES
ClC1=CC2=C(C=C1)C(N3CCN(S(C4=CC=C([N+]([O-])=O)C=C4[N+]([O-])=O)(=O)=O)CC3)=CC=N2
InChi Code
InChI=1S/C19H16ClN5O6S/c20-13-1-3-15-16(11-13)21-6-5-17(15)22-7-9-23(10-8-22)32(30,31)19-4-2-14(24(26)27)12-18(19)25(28)29/h1-6,11-12H,7-10H2
InChi Key
PDQVZPPIHADUOO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Cayman Chemical
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    Product Description

    VR23 is a chloroquine (Item No. 14194) derivative that functions as a proteasome inhibitor (IC50s = 1 nM, 50-100 nM, and 3 µM for trypsin-like, chymotrypsin-like, and caspase-like proteasomes, respectively).1 It also deregulates the activity of cyclin E and other centrosomal proteins, resulting in the induction of multiple centrosome amplification, abnormal spindle formation, uneven cytokinesis, irreversible mitotic arrest, and eventually apoptosis that is specific to cancer cells.1 In combination with the chymotrypsin-like proteasome inhibitor bortezomib (Item No. 10008822), VR23 can produce a synergistic effect in killing multiple myeloma cells, including those that are resistant to bortezomib.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pundir, S., Vu, H.Y., Solomon, V.R., et al. VR23: A quinoline-sulfonyl hybrid proteasome inhibitor that selectively kills cancer via cyclin E-mediated centrosome amplification. Cancer Res. 75(19), 4164-4175 (2015).