An inducer of Oct3/4
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O4I2

Item No. 19135

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(4-chlorophenyl)amino]- 4-thiazolecarboxylic acid, ethyl ester
CAS Number
165682-93-9
Molecular Formula
C12H11ClN2O2S
Formula Weight
282.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2); (1:7): 0.12 mg/mlDMSO: 30 mg/mlEthanol: 20 mg/ml
λmax
276 nm
SMILES
ClC1=CC=C(NC2=NC(C(OCC)=O)=CS2)C=C1
InChi Code
InChI=1S/C12H11ClN2O2S/c1-2-17-11(16)10-7-18-12(15-10)14-9-5-3-8(13)4-6-9/h3-7H,2H2,1H3,(H,14,15)
InChi Key
ULUBAPWNHROTEU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $95

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    10 mg

    $129

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    25 mg

    $294

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    Product Description

    O4I2 is a potent inducer of Oct3/4 expression and translation in human cell lines, including embryonic kidney HEK293, embryonic placental NCCIT, and Oct-deficient HeLa cells.1 It also induces Oct3/4 expression and translation in terminally differentiated human fibroblasts. Through this action, O4I2 promotes the expression of pluripotency-associated genes in human neonatal foreskin fibroblasts.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cheng, X., Yoshida, H., Raoofi, D., et al. Ethyl 2-((4-Chlorophenyl)amino)thiazole-4-carboxylate and derivatives are potent inducers of Oct3/4. J. Med. Chem. 58(15), 5742-5750 (2015).