A partial agonist of dopamine D1-like receptors
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SKF 38393 (hydrobromide)

Item No. 19150

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,3,4,5-tetrahydro-1-phenyl-1H-3-benzazepine-7,8-diol, monohydrobromide
CAS Number
20012-10-6
Molecular Formula
C16H17NO2 • HBr
Formula Weight
336.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2) (1:20): 0.04 mg/mlEthanol: 2 mg/ml
λmax
286 nm
SMILES
OC(C(O)=C1)=CC2=C1C(CNCC2)C3=CC=CC=C3.Br
InChi Code
InChI=1S/C16H17NO2.BrH/c18-15-8-12-6-7-17-10-14(13(12)9-16(15)19)11-4-2-1-3-5-11;/h1-5,8-9,14,17-19H,6-7,10H2;1H
InChi Key
INNWVRBZMBCEJI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $40

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    25 mg

    $86

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    50 mg

    $143

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    100 mg

    $190

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    Product Description

    SKF 38393 is a partial agonist of the dopamine D1-like receptors D1 and D5 (Kis = 1 and ~0.5 nM, respectively).1 It less potently binds D2, D3, and D4 receptors (Kis = ~150, 5,000, and 1,000 nM, respectively).2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Seeman, P., and Van Tol, H.H.M. Dopamine receptor pharmacology. Trends Pharmacol. Sci. 15(7), 264-270 (1994).

    2. Bolotina, V.M. Orai, STIM1 and iPLA2β: A view from a different perspective. J. Physiol. 586(13), 3035-3042 (2008).

    3. Neumeyer, J.L., Kula, N.S., Bergman, J., et al. Receptor affinities of dopamine D1 receptor-selective novel phenylbenzazepines. Eur. J. Pharmacol. 474(2-3), 137-140 (2003).