A purine nucleoside analog
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6-thio-2′-Deoxyguanosine

Item No. 19154

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2'-deoxy-6-thio-guanosine
CAS Number
789-61-7
Synonyms
  • ​6-thio-dG
  • NSC 71261
  • β-Thioguanine deoxyriboside
Molecular Formula
C10H13N5O3S
Formula Weight
283.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS (pH 7.2) (1:1): 0.5 mg/mlDMSO: 20 mg/ml
λmax
209, 259, 346 nm
SMILES
O[C@H]1C[C@H](N2C=NC3=C2N=C(N)NC3=S)O[C@@H]1CO
InChi Code
InChI=1S/C10H13N5O3S/c11-10-13-8-7(9(19)14-10)12-3-15(8)6-1-4(17)5(2-16)18-6/h3-6,16-17H,1-2H2,(H3,11,13,14,19)/t4-,5+,6+/m0/s1
InChi Key
SCVJRXQHFJXZFZ-KVQBGUIXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $36

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    5 mg

    $103

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    10 mg

    $135

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    25 mg

    $319

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    Cayman Chemical
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    Product Description

    6-thio-2′-Deoxyguanosine (6-thio-dG) is a purine nucleoside analog. It reduces infection of Calu-3 cells by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; EC50 = 0.04 µM) but is also toxic to Calu-3 cells with a 50% cytotoxic concentration (CC50) value of 1.14 µM.1 6-Thio-dG (2 mg/kg) decreases tumor volume and increases the number of tumor cells with telomere dysfunction-induced foci in an A549 non-small cell lung cancer (NSCLC) mouse xenograft model.2 It increases the number of programmed cell death protein 1 (PD-1) positive CD8+ T cells, as well as induces tumor regression when administered in combination with an antibody against PD-1 ligand (PD-L1) in MC-38 murine colon carcinoma models.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Schultz, D.C., Johnson, R.M., Ayyanathan, K., et al. Pyrimidine inhibitors synergize with nucleoside analogues to block SARS-CoV-2. Nature 604(7904), 134-140 (2022).

    2. Mender, I., Gryaznov, S., Dikmen, Z.G., et al. Induction of telomere dysfunction mediated by the telomerase substrate precursor 6-thio-2'-deoxyguanosine. Cancer Discov. 5(1), 82-95 (2015).

    3. Mender, I., Zhang, A., Ren, Z., et al. Telomere stress potentiates STING-dependent anti-tumor immunity. Cancer Cell 38(3), 400-411 (2020).