An AMPK activator
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GSK621

Item No. 19155

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-chloro-5-(2'-hydroxy-3'-methoxy[1,1'-biphenyl]-4-yl)-3-(3-methoxyphenyl)-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione
CAS Number
1346607-05-3
Molecular Formula
C26H20ClN3O5
Formula Weight
489.9
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml
λmax
273 nm
SMILES
COC1=CC=CC(N2C(C(N(C3=CC=C(C4=CC=CC(OC)=C4O)C=C3)C(Cl)=C5)=C5NC2=O)=O)=C1
InChi Code
InChI=1S/C26H20ClN3O5/c1-34-18-6-3-5-17(13-18)30-25(32)23-20(28-26(30)33)14-22(27)29(23)16-11-9-15(10-12-16)19-7-4-8-21(35-2)24(19)31/h3-14,31H,1-2H3,(H,28,33)
InChi Key
KURYSXLJGKKDHT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $63

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    5 mg

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    10 mg

    $274

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    25 mg

    $602

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    Cayman Chemical
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    Product Description

    GSK621 is an activator of AMP-activated protein kinase (AMPK). It has been shown to increase phosphorylation at AMPKα T172, a marker of AMPK activation, in both acute myeloid leukemia (AML) cell lines and primary AML samples.1 GSK621 is reported to reduce the proliferation of AML cell lines (IC50s = 13-30 μM), triggering autophagy via the eIF2α/ATF4 signaling pathway.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sujobert, P., Poulain, L., Paubelle, E., et al. Co-activation of AMPK and mTORC1 induces cytotoxicity in acute myeloid leukemia. Cell Rep. 11(9), 1446-1457 (2015).