A non-selective COX inhibitor
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Diflunisal

Item No. 19187

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2',4'-difluoro-4-hydroxy-[1,1'-biphenyl]-3-carboxylic acid
CAS Number
22494-42-4
Synonyms
  • 5-(2,4-Difluorophenyl)salicylic Acid
  • MK-647
Molecular Formula
C13H8F2O3
Formula Weight
250.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 25 mg/mlEthanol: 25 mg/ml
λmax
228, 253 nm
SMILES
FC1=CC(F)=C(C2=CC=C(O)C(C(O)=O)=C2)C=C1
InChi Code
InChI=1S/C13H8F2O3/c14-8-2-3-9(11(15)6-8)7-1-4-12(16)10(5-7)13(17)18/h1-6,16H,(H,17,18)
InChi Key
HUPFGZXOMWLGNK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

    $49

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    10 g

    $93

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    25 g

    $213

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    50 g

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    Product Description

    Diflunisal is a non-steroidal anti-inflammatory drug (NSAID) that inhibits both COX-1 (IC50 = 113 µM) and COX-2 (IC50s = 8.2 and 134 µM for human whole blood assay and human-modified whole blood assays, respectively).1 Peak plasma levels are achieved within two hours, with little metabolism before excretion in the urine.2 The terminal plasma half-life is approximately eight hours.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Warner, T.D., Giuliano, F., Vojnovic, I., et al. Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis. Proc. Natl. Acad. Sci. USA 96(13), 7563-7568 (1999).

    2. Tempero, K.F., Cirillo, V.J., and Steelman, S.L. Diflunisal: A review of pharmacokinetic and pharmacodynamic properties, drug interactions, and special tolerability studies in humans. Br. J. Clin. Pharmacol. 4 Suppl 1, 31S-36S (1977).