An inhibitor of fibrinolysis
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Labeled Version(s)
28804Tranexamic Acid-13C2,15N
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Product Categories

Product Type

Biochemicals

Research Area

Endocrinology & Metabolism

Tranexamic Acid

Item No. 19193

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
trans-4-(aminomethyl)-cyclohexanecarboxylic acid
CAS Number
1197-18-8
Synonyms
  • AMCA
  • TXA
Molecular Formula
C8H15NO2
Formula Weight
157.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
SMILES
OC([C@@H]1CC[C@@H](CN)CC1)=O
InChi Code
InChI=1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)/t6-,7-
InChi Key
GYDJEQRTZSCIOI-LJGSYFOKSA-N
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
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    25 g

    $36

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    50 g

    $68

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    100 g

    $117

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    250 g

    $253

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    Product Description

    Tranexamic acid is an inhibitor of fibrinolysis that inhibits the interaction of plasmin with fibrin (IC50 = 3.1 µM in isolated human plasma).1 It decreases α-naphthylisothiocyanate (ANIT)-induced increases in the expression of the profibrogenic genes Timp1 and Col1a1, but not Itgb6, Tgfβ1, or Tgfβ2, and reduces protein levels of cytokeratin 19 (CK19) and type I collagen in the liver after 28 days in a mouse model of chronic bile duct injury.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Boström, J., Grant, J.A., Fjellström, O., et al. Potent fibrinolysis inhibitor discovered by shape and electrostatic complementarity to the drug tranexamic acid. J. Med. Chem. 56(8), 3273-3280 (2013).

    2. Joshi, N., Kopec, A.K., Towery, K., et al. The antifibrinolytic drug tranexamic acid reduces liver injury and fibrosis in a mouse model of chronic bile duct injury. J. Pharmacol. Exp. Ther. 349(3), 383-392 (2014).