An inhibitor of kynurenine 3-monooxygenase
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GSK180

Item No. 19217

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,6-dichloro-2-oxo-3(2H)-benzoxazolepropanoic acid
CAS Number
1799725-26-0
Molecular Formula
C10H7Cl2NO4
Formula Weight
276.1
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/ml
SMILES
O=C1N(CCC(O)=O)C2=CC(Cl)=C(Cl)C=C2O1
InChi Code
InChI=1S/C10H7Cl2NO4/c11-5-3-7-8(4-6(5)12)17-10(16)13(7)2-1-9(14)15/h3-4H,1-2H2,(H,14,15)
InChi Key
MIGAKMWKMLYGJX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $39

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    5 mg

    $164

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    10 mg

    $270

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    25 mg

    $482

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    Product Description

    GSK180 is an inhibitor of kynurenine 3-monooxygenase (IC50 = 6.3 nM).1 It is selective for human over P. fluorescens kynurenine 3-monooxygenase (IC50 = 500 nM). GSK180 (27 mg/kg) increases circulating levels of kynurenine and kynurenic acid in mice.2 It protects against secondary acute lung injury and renal injury in a rat model of experimentally induced acute pancreatitis multiple organ dysfunction syndrome (AP-MODS).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liddle, J., Beaufils, B., Binnie, M., et al. The discovery of potent and selective kynurenine 3-monooxygenase inhibitors for the treatment of acute pancreatitis. Bioorg. Med. Chem. Lett. 27(9), 2023-2028 (2017).

    2. Mole, D.J., Webster, S.P., Uings, I., et al. Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis. Nat. Med. 22(2), 202-209 (2016).