An antifungal agent
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Labeled Version(s)
29413Naftifine-d3 (hydrochloride)
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Naftifine (hydrochloride)

Item No. 19234

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-methyl-N-[(2E)-3-phenyl-2-propen-1-yl]-1-naphthalenemethanamine, monohydrochloride
CAS Number
65473-14-5
Synonyms
  • AW 105-843
Molecular Formula
C21H21N • HCl
Formula Weight
323.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS (pH 7.2) (1:5): 0.16 mg/mlDMSO: 5 mg/mlEthanol: 5 mg/ml
λmax
222, 255, 282 nm
SMILES
CN(C/C=C/C1=CC=CC=C1)CC2=C(C=CC=C3)C3=CC=C2.Cl
InChi Code
InChI=1S/C21H21N.ClH/c1-22(16-8-11-18-9-3-2-4-10-18)17-20-14-7-13-19-12-5-6-15-21(19)20;/h2-15H,16-17H2,1H3;1H/b11-8+;
InChi Key
OLUNPKFOFGZHRT-YGCVIUNWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Naftifine is an allylamine compound that blocks ergosterol biosynthesis in fungi by inhibiting squalene epoxidase (Ki = 1.1 µM for C. albicans epoxidase).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ryder, N.S., and Dupont, M.C. Inhibition of squalene epoxidase by allylamine antimycotic compounds. A comparative study of the fungal and mammalian enzymes. Biochem. J. 230(3), 765-770 (1985).