An agonist of PPARα, PPARγ, and PPARδ and an active metabolite of fenofibrate
Related Products
Pro-drug Form(s)
10005368Fenofibrate
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Fenofibric Acid

Item No. 19262

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-propanoic acid
CAS Number
42017-89-0
Synonyms
  • FNF Acid
  • NSC 281318
  • Procetofenic Acid
Molecular Formula
C17H15ClO4
Formula Weight
318.8
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 14 mg/mLDMSO: 2 mg/mLEthanol: 16 mg/mLPBS (pH 7.2): 0.5 mg/mL
λmax
288 nm
SMILES
ClC1=CC=C(C(C2=CC=C(OC(C)(C)C(O)=O)C=C2)=O)C=C1
InChi Code
InChI=1S/C17H15ClO4/c1-17(2,16(20)21)22-14-9-5-12(6-10-14)15(19)11-3-7-13(18)8-4-11/h3-10H,1-2H3,(H,20,21)
InChi Key
MQOBSOSZFYZQOK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
4°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 mg

    $36

    Add

    1 g

    $68

    Add

    5 g

    $236

    Add

    10 g

    $436

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    Fenofibric acid is an agonist of peroxisome proliferator-activated receptor α (PPARα), PPARγ, and PPARδ (EC50s = 22.4, 1.47, and 1.06 µM, respectively, in a transactivation assay) and an active metabolite of the PPARα agonist fenofibrate (Item No. 10005368).1,2 It is formed by the hydrolysis of fenofibrate in tissue.1 It inhibits COX-2 activity in a cell-free assay (IC50 = 0.048 µM).3 Fenofibric acid (500 µM) reduces aldehyde oxidase 1 (AOX1) protein levels in HepG2 cells.4 Fenofibric acid (10 mg/kg) reduces carrageenan-induced paw edema in rats.3 Formulations containing fenofibric acid have been used in the treatment of high cholesterol and hypertriglyceridemia.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Caldwell, J. The biochemical pharmacology of fenofibrate. Cardiology 76(Suppl 1), 33-44 (1989).

    2. Dietz, M., Mohr, P., Kuhn, B., et al. Comparative molecular profiling of the PPARα/γ activator aleglitazar: PPAR selectivity, activity and interaction with cofactors. ChemMedChem 7(6), 1101-1111 (2012).

    3. Prasad, G.S., Govardhan, P., Deepika, G., et al. Anti-inflammatory activity of anti-hyperlipidemic drug, fenofibrate, and its phase-I metabolite fenofibric acid: in silico, in vitro, and in vivo studies. Inflammopharmacology 26(4), 973-981 (2018).

    4. Neumeier, M., Weigert, J., Schäffler, A., et al. Aldehyde oxidase 1 is highly abundant in hepatic steatosis and is downregulated by adiponectin and fenofibric acid in hepatocytes in vitro. Biochem. Biophys. Res. Commun. 350(3), 731-735 (2006).