An inducer of non-apoptotic cell death
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Product Type

Biochemicals

Research Area

CIL56

Item No. 19287

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,7-bis(1-piperidinylsulfonyl)-9H-fluoren-9-one, oxime
CAS Number
300802-28-2
Molecular Formula
C23H27N3O5S2
Formula Weight
489.6
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlDMSO:PBS (pH 7.2)(1:9): 0.1 mg/mlEthanol: 0.1 mg/ml
λmax
224, 267, 308 nm
SMILES
O=S(C1=CC2=C(C=C1)C3=CC=C(S(N4CCCCC4)(=O)=O)C=C3/C2=N\O)(N5CCCCC5)=O
InChi Code
InChI=1S/C23H27N3O5S2/c27-24-23-21-15-17(32(28,29)25-11-3-1-4-12-25)7-9-19(21)20-10-8-18(16-22(20)23)33(30,31)26-13-5-2-6-14-26/h7-10,15-16,27H,1-6,11-14H2
InChi Key
XYZXEEIUKQGUHB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

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    Product Description

    CIL56 is a small molecule that induces non-apoptotic cell death in a manner dependent on acetyl-CoA carboxylase 1 (ACC1), the rate-limiting enzyme in fatty acid synthesis.1 HT-1080 cells lacking ACC1 exhibit 5-fold resistance to CIL56 treatment, indicating ACC1 activity sensitizes cells to CIL56-induced cell death. CIL56 (6.5 μM) induces accumulation of long-chain saturated, monounsaturated, and polyunsaturated fatty acids in HT-1080 cells in vitro.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dixon, S.J., Winter, G.E., Musavi, L.S., et al. Human haploid cell genetics reveals roles for lipid metabolism genes in nonapoptotic cell death. ACS Chem. Biol. 10(7), 1604-1609 (2015).