Deuterated Primary Prostaglandin Metabolite MaxSpec^® LC-MS Mixture

The Deuterated Primary Prostaglandin Metabolite MaxSpec^® LC-MS Mixture contains deuterated forms of selected eicosanoids produced by the metabolism of arachidonic acid via the COX pathway. The mixture is supplied in an amber ampule in which the headspace has been purged with argon to prevent lipid oxidation. This product has been designed for direct use in LC-MS applications. This mixture is ideally suited for use as an internal standard in mass spectrometry applications. It should be noted that the mixture contains isobaric analytes. After opening, we recommend that the mixture be transferred immediately to a 1 ml glass screw cap vial, to prevent solvent evaporation, and stored at -20°C. The mixture should be discarded after multiple freeze/thaw cycles.

Prostaglandin (PG) D₂ (Item No. 12010), PGE₂ (Item No. 14010), and PGF_2α (Item No. 16010) are metabolized rapidly by the 15-hydroxy PG dehydrogenase pathway, giving 13,14-dihydro-15-keto PGD₂ (Item No. 12610), 13,14-dihydro-15-keto PGE₂ (Item No. 14650), and 13,14-dihydro-15-keto PGF_2α (Item No. 16670), respectively. PGD₂ is also metabolized to 11β-PGF_2α (Item No. 16520) by 11-ketoreductase and non-enzymatically to 15-deoxy-Δ^12,14-PGJ₂ (Item No. 18570). This mixture contains deuterated forms of these five metabolites.

WARNING This product is not for human or veterinary use.

Tufail, Y.Z., Guijas, C., Kummer, D.A., et al. Suppression of pain transmission and behavior by inhibition of peripheral diacylglycerol metabolism. Cell Chem. Bio. 33(1), 74-90.e19 (2025).