A selective FAAH inhibitor
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PF-04457845

Item No. 19306

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-3-pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methylene]-1-piperidinecarboxamide
CAS Number
1020315-31-4
Molecular Formula
C23H20F3N5O2
Formula Weight
455.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS (pH 7.2) (1:5): 0.16 mg/mlDMSO: 20 mg/mlEthanol: 5 mg/ml
λmax
243 nm
SMILES
O=C(NC1=CC=CN=N1)N(CC/2)CCC2=C\C3=CC=CC(OC4=CC=C(C(F)(F)F)C=N4)=C3
InChi Code
InChI=1S/C23H20F3N5O2/c24-23(25,26)18-6-7-21(27-15-18)33-19-4-1-3-17(14-19)13-16-8-11-31(12-9-16)22(32)29-20-5-2-10-28-30-20/h1-7,10,13-15H,8-9,11-12H2,(H,29,30,32)
InChi Key
BATCTBJIJJEPHM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $75

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    10 mg

    $134

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    25 mg

    $315

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    50 mg

    $589

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    Product Description

    PF-04457845 is an orally active, irreversible inhibitor of fatty acid amide hydrolase (FAAH; IC50 = 7.2 nM) that is selective against other serine hydrolases.1 It is a covalent inhibitor that carbamylates the active site serine nucleophile of FAAH.1 In a rat model of inflammatory pain, oral administration of 0.1 mg/kg PF-04457845 has been shown to reduce inflammatory pain with efficacy comparable to that of naproxen.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Johnson, D.S., Stiff, C., Lazerwith, S.E., et al. Discovery of PF-04457845: A highly potent, orally bioavailable, and selective urea FAAH inhibitor. ACS Med. Chem. Lett. 2(2), 91-96 (2011).