A selenium-NSAID hybrid
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Se-Aspirin

Item No. 19315

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
selenocyanic acid, 2-[[2-(acetyloxy)benzoyl]amino]ethyl ester
CAS Number
1850293-95-6
Synonyms
  • Selenium-acetylsalicylic Acid
Molecular Formula
C12H12N2O3Se
Formula Weight
311.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMF:PBS (pH 7.2) (1:1): 0.5 mg/mlDMSO: 30 mg/mlEthanol: 10 mg/ml
SMILES
O=C(C)OC1=CC=CC=C1C(NCC[Se]C#N)=O
InChi Code
InChI=1S/C12H12N2O3Se/c1-9(15)17-11-5-3-2-4-10(11)12(16)14-6-7-18-8-13/h2-5H,6-7H2,1H3,(H,14,16)
InChi Key
YJLOEJJBOLNYTM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $36

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    5 mg

    $153

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    10 mg

    $268

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    50 mg

    $1,086

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    Product Description

    Se-Aspirin is a hybrid of selenium and a nonsteroidal anti-inflammatory drug that has been shown to reduce the viability of different cancer cell lines, particularly colorectal cancer (CRC) cells (IC50 = 3.4 µM).1 It can inhibit the cell cycle in G1 and G2/M phases and induce apoptosis by activating caspase 3/7 and PARP cleavage.1 Long-term exposure to Se-Aspirin is reported to cause an increase in intracellular reactive oxygen species levels in CRC cells.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Plano, D., Karelia, D.N., Pandey, M.K., et al. Design, synthesis, and biological evaluation of novel selenium (Se-NSAID) molecules as anticancer agents. J. Med. Chem. 59(5), 1946-1959 (2016).