An internal standard for the quantification of 13,14-dihydro-15-keto PGD2
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

13,14-dihydro-15-keto Prostaglandin D2-d9

Item No. 19334

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9α-hydroxy-11,15-dioxo-prost-5Z-en-1-oic-17,17,18,18,19,19,20,20,20-d9 acid
CAS Number
2738376-77-5
Synonyms
  • 13,14-dihydro-15-keto-PGD2-d9
Molecular Formula
C20H23D9O5
Formula Weight
361.5
Purity
≥99% deuterated forms (d1-d9)
Formulation
A 500 µg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 30 mg/mlEthanol: 50 mg/mlPBS (pH 7.2): 1 mg/ml
SMILES
O[C@@H](C1)[C@H](C/C=C\CCCC(O)=O)[C@@H](CCC(CC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])=O)C1=O
InChi Code
InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,16-18,22H,2-3,5-6,8-14H2,1H3,(H,24,25)/b7-4-/t16-,17-,18+/m1/s1/i1D3,2D2,3D2,6D2
InChi Key
VSRXYLYXIXYEST-GQOYKKFZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    50 µg

    $193

    Add

    100 µg

    $362

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    13,14-dihydro-15-keto-Prostaglandin D2-d9 (13,14-dihydro-15-keto PGD2-d9) is intended for use as an internal standard for the quantification of 13,14-dihydro-15-keto PGD2 (Item No. 12610) by GC- or LC-MS. 13,14-dihydro-15-keto PGD2 is a metabolite of PGD2 (Item No. 12010) which is formed through the 15-hydroxy PGDH pathway. 13,14-dihydro-15-keto PGD2 was recently identified as a selective agonist for the CRTH2/DP2 receptor.1 It also inhibits ion flux in a canine colonic mucosa preparation.2 In humans, 13,14-dihydro-15-keto PGD2 is further metabolized to give 11β-hydroxy compounds which have also undergone β-oxidation of one or both side chains. Virtually no 13,14-dihydro-15-keto PGD2 survives intact in the urine.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rangachari, P.K., and Betti, P.A. Biological activity of metabolites of PGD2 on canine proximal colon. Am. J. Physiol. 264(5 Pt 1), G886-G894 (1993).

    2. Hirai, H., Tanaka, K., Yoshie, O., et al. Prostaglandin D2 selectivity induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2. J. Exp. Med. 193(2), 255-261 (2001).

    3. Liston, T.E., and Roberts, L.J., II Metabolic fate of radiolabeled prostaglandin D2 in a normal human male volunteer. The Journal of Biological Chemisty 260(24), 13172-13180 (1985).

    4. Morrow, J.D., Prakash, C., Awad, J.A., et al. Quantification of the major urinary metabolite of prostaglandin D2 by a stable isotope dilution mass spectrometric assay. Anal. Biochem. 193(1), 142-148 (1991).