An internal standard for the quantification of 15-deoxy-Δ12,14-PGJ2
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15-deoxy-Δ12,14-Prostaglandin J2-d9

Item No. 19347

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
11-oxo-prosta-5Z,9,12E,14E-tetraen-1-oic acid-d9
Synonyms
  • 15-deoxy-Δ12,14-PGJ2-d9
Molecular Formula
C20H19D9O3
Formula Weight
325.5
Purity
≥99% deuterated forms (d1-d9)
Formulation
A 1 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 50 mg/mlEthanol: 50 mg/mlPBS (pH 7.2): 1 mg/ml
SMILES
O=C1/C([C@@H](C/C=C\CCCC(O)=O)C=C1)=C/C=C/CC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H]
InChi Code
InChI=1S/C20H28O3/c1-2-3-4-5-6-10-13-18-17(15-16-19(18)21)12-9-7-8-11-14-20(22)23/h6-7,9-10,13,15-17H,2-5,8,11-12,14H2,1H3,(H,22,23)/b9-7-,10-6+,18-13+/t17-/m0/s1/i1D3,2D2,3D2,4D2
InChi Key
VHRUMKCAEVRUBK-ALEWIJCRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    100 µg

    $387

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    Product Description

    15-deoxy-Δ12,14-Prostaglandin J2-d9 (15-deoxy-Δ12,14-PGJ2-d9) is intended for use as an internal standard for the quantification of 15-deoxy-Δ12,14-PGJ2 (Item No. 18570 | 18570.1) by GC- or LC-MS. 15-deoxy-Δ12,14-PGJ2 is formed from PGD2 (Item No. 12010) by the elimination of two molecules of water. It binds selectively to PPARγ with an EC50 value of 2 µM in a murine chimera system.1,2 15-deoxy-Δ12,14-PGJ2 is more potent than PGD2, Δ12-PGJ2 (Item No. 18550), and PGJ2 (Item No. 18500) in stimulating lipogenesis in C3H10T1/2 cells. The EC50 for induction of adipocyte differentiation in cultured fibroblasts is 7 µM.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kliewer, S.A., Lenhard, J.M., Willson, T.M., et al. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation. Cell 83(5), 813-819 (1995).

    2. Forman, B.M., Tontonoz, P., Chen, J., et al. 15-Deoxy-Δ12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ. Cell 83(5), 803-812 (1995).

    Product Citations

    Tufail, Y.Z., Guijas, C., Kummer, D.A., et al. Suppression of pain transmission and behavior by inhibition of peripheral diacylglycerol metabolism. Cell Chem. Bio. 33(1), 74-90.e19 (2025).