Pyridoxal isonicotinoyl hydrazone

Pyridoxal isonicotinoyl hydrazine is a lipophilic, nontoxic, iron-chelating agent that shows high iron chelation efficacy both in vitro in cell culture models and in vivo in rats and mice.^1,2 Because iron is a crucial component of metabolic pathways involved in DNA synthesis, cancerous cells have a high iron requirement due to rapid rates of proliferation. While pyridoxal isonicotinoyl hydrazine exhibits low anticancer activity, its analogs demonstrate antiproliferative effects in a range of tumor cells.^3,4,5

WARNING This product is not for human or veterinary use.

1. Ponka, P., Borova, J., Neuwirt, J., et al. Mobilization of iron from reticulocytes. Identification of pyridoxal isonicotinoyl hydrazone as a new iron chelating agent. FEBS Lett. 97(2), 317-321 (1979).

2. Richardson, D.R., and Ponka, P. Pyridoxal isonicotinoyl hydrazone and its analogs: Potential orally effective iron-chelating agents for the treatment of iron overload disease. J. Lab. Clin. Med. 131(4), 306-315 (1998).

3. Merlot, A.M., Pantarat, N., Lovejoy, D.B., et al. Membrane transport and intracellular sequestration of novel thiosemicarbazone chelators for the treatment of cancer. Mol. Pharmacol. 78(4), 675-684 (2010).

4. Richardson, D.R. Cytotoxic analogs of the iron(III) chelator pyridoxal isonicotinoyl hydrazone: Effects of complexation with copper(II), gallium(III), and iron (III) on their antiproliferative activities. Antimicrob. Agents Chemother. 41(9), 2061-2063 (1997).

5. Gao, J., and Richardson, D.R. The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents, IV: The mechanisms involved in inhibiting cell-cycle progression. Blood 98(3), 842-850 (2001).