A calmodulin inhibitor
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E6 Berbamine

Item No. 19358

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,4,4aS,5,16aR,17,18,19-octahydro-21,22,26-trimethoxy-4,17-dimethyl-16H-1,24:6,9-dietheno-11,15-metheno-2H-pyrido[2’,3’:17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolin-12-ol-4-nitrobenzoate
Synonyms
  • Berbamine p-nitrobenzoate
  • O-(4-Nitrobenzoyl)berbamine
Molecular Formula
C44H43N3O9
Formula Weight
757.8
Purity
≥98% (mixture of enantiomers)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 25mMEthanol: 25mM
SMILES
COC1=C(C2=C(CCN([C@]2([H])CC3=CC=C(OC(C4=CC=C([N+]([O-])=O)C=C4)=O)C(OC5=CC=C(C[C@@]67[H])C=C5)=C3)C)C=C1OC)OC8=CC6=C(CCN7C)C=C8OC
InChi Code
InChI=1S/C44H43N3O9/c1-45-18-16-29-23-37(51-3)39-25-33(29)34(45)20-26-6-13-32(14-7-26)54-38-22-27(8-15-36(38)56-44(48)28-9-11-31(12-10-28)47(49)50)21-35-41-30(17-19-46(35)2)24-40(52-4)42(53-5)43(41)55-39/h6-15,22-25,34-35H,16-21H2,1-5H3/t34-,35+/m0/s
InChi Key
PUAVTDKYTXNVBU-OIDHKYIRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    10 mg

    $141

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    50 mg

    $667

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    Product Description

    E6 Berbamine is a calmodulin inhibitor that disrupts the activity of calmodulin-dependent enzymes such as myosin light chain kinase (IC50 = 8 µM) and phosphodiesterase 1A (IC50 = 0.53 µM).1 It is also reported to inhibit P-glycoprotein activity in purified primary cultured rat brain microvessel endothelial cells at 10 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hu, Z.Y., Gong, Y.S., and Huang, W.L. Interaction of berbamine compound E6 and calmodulin-dependent myosin light chain kinase. Biochem. Pharmacol. 44(8), 1543-1547 (1992).

    2. Zhu, H.J., and Liu, G.Q. Effect of E6, a novel calmodulin inhibitor, on activity of P-glycoprotein in purified primary cultured rat brain microvessel endothelial cells. Acta Pharmacol. Sin. 24(11), 1143-1149 (2003).