An activator of p53 and inhibitor of NF-κB
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Alternative(s)
19110CBL0137
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CBL0137 (hydrochloride)

Item No. 19373

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,1'-[9-[2-[(1-methylethyl)imino]ethyl]-9H-carbazole-3,6-diyl]bis-ethanone, monohydrochloride
CAS Number
1197397-89-9
Synonyms
  • CBLC137
  • Curaxin 137
Molecular Formula
C21H24N2O2 • HCl
Formula Weight
372.9
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 25 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
259, 290, 327 nm
SMILES
CC(C1=CC=C2C(C(C=C(C(C)=O)C=C3)=C3N2CCNC(C)C)=C1)=O.Cl
InChi Code
InChI=1S/C21H24N2O2.ClH/c1-13(2)22-9-10-23-20-7-5-16(14(3)24)11-18(20)19-12-17(15(4)25)6-8-21(19)23;/h5-8,11-13,22H,9-10H2,1-4H3;1H
InChi Key
IXRKBBVMDMKAEB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    10 mg

    $999

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    Cayman Chemical
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    Product Description

    CBL0137 is a water soluble and metabolically stable curaxin that activates p53 with an EC50 value of 0.37 µM and inhibits NF-κB with an EC50 value of 0.47 µM.1 It functionally inactivates the facilitates chromatin transcription complex, driving the effects on p53 and NF-κB and promoting cancer cell death.1 CBL0137 has broad anticancer activity in mice when administered orally, eradicates drug-resistant cancer stem cells, and potentiates efficacy of gemcitabine (Item No. 11690) in preclinical models of pancreatic cancer.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gasparian, A.V., Burkhart, C.A., Purmal, A.A., et al. Curaxins: Anticancer compounds that simultaneously suppress NF-κB and activate p53 by targeting FACT. Sci. Transl. Med. 3(95), (2011).

    2. Burkhart, C., Fleyshman, D., Kohrn, R., et al. Curaxin CBL0137 eradicates drug resistant cancer stem cells and potentiates efficacy of gemcitabine in preclinical models of pancreatic cancer. Oncotarget 5(22), 11038-11053 (2014).